Projects Available for Students
Intermittent fasting is an effective intervention for the treatment of metabolic disease. But how the proteome in each tissue is reprogrammed by this dietary intervention is currently unknown. Our goal is to use state-of-the-art proteomic analysis to uncover the complex interaction between organ systems that leads to the beneficial effects of intermittent fasting.
Characterisation of erusiolin a novel putative hormone
Using our SPEA methodology and unbiased mass spectrometry-based proteomics has allowed us to identify several new putative hormones in human plasma. Erusiolin is among these, which we hypothesise plays a role in appetite regulation. Our goal is to characterise the role of this hormone in mammalian physiology using human clinical trial samples, CRISPR knock-out mice, peptide injection experiments and bioinformatic analysis.
Mapping protein-protein interactions